Banca de DEFESA: JHULIMAR GUILHERME DOERL

Uma banca de DEFESA de DOUTORADO foi cadastrada pelo programa.
STUDENT : JHULIMAR GUILHERME DOERL
DATE: 29/05/2024
TIME: 09:00
LOCAL: https://meet.google.com/kzc-wqer-qnr
TITLE:

Description of cerebrospinal fluid dynamics and morphological changes associated with Zika virus infection in developing mice.

KEY WORDS:

Zika virus; Glymphatic system; Postnatal development; Zika virus congenital syndrome;

PAGES: 72
BIG AREA: Ciências Biológicas
AREA: Fisiologia
SUMMARY:

Since 2015, the increase in cases of congenital Zika virus (ZIKV) infection has aroused great interest in the scientific community, especially in Brazil. The infection results in various lesions and malformations in the central nervous system (CNS). The resulting phenotypes are diverse, with patients exhibiting different degrees of impairment. Many patients with congenital Zika virus syndrome (CZVS) develop progressive malformations, even after birth and cessation of signs of ZIKV infection. These findings suggest that ZIKV causes inflammation of the neural tissue that can persist for a prolonged period. The glymphatic system, responsible for removing products of cellular metabolism and other molecules from the ISF and CSF, is essential for neural tissue homeostasis. The formation of the glymphatic system occurs after the genesis of vessels within the parenchyma, the differentiation of radial glia cells into astrocytes and the formation of astrocyte extensions near the blood-brain barrier (BBB). Recent research indicates that ZIKV infects developing astrocytes and can affect the formation of their projections around blood vessels. Although there are indications that the virus alters the glymphatic system, no studies have yet been carried out to test the effect of this infection. Therefore, in this study, we characterized the impact of ZIKV infection on gliogenesis and the development of the glymphatic system. We observed that the severity of infection symptoms is related to age and the viral load administered. Our infection model reproduced morphological and structural alterations similar to those observed in children with CZVS. In addition, we found that ZIKV infection alters the dynamics of CSF flow and the expression of Aqp4, suggesting a dysfunction of the glymphatic system.

COMMITTEE MEMBERS:
Externo à Instituição - LEO MORITA MIYAKOSHI - IP
Externa à Instituição - JAQUELINE DA SILVA GENEROSO - UNESC
Presidente - 2394627 - EDUARDO BOUTH SEQUERRA
Interna - 1976236 - EMELIE KATARINA SVAHN LEAO
Externo à Instituição - PATRICIA PESTANA GARCEZ - KCL