Banca de QUALIFICAÇÃO: ARTHUR FERNANDO SILVA ANDRADE DOS SANTOS

Uma banca de QUALIFICAÇÃO de MESTRADO foi cadastrada pelo programa.
STUDENT : ARTHUR FERNANDO SILVA ANDRADE DOS SANTOS
DATE: 30/05/2025
TIME: 14:30
LOCAL: VIDEOCONFERÊNCIA
TITLE:

DEVELOPMENT OF LOW-ENERGY NANOEMULSION SYSTEMS CONTAINING PRAZIQUANTEL FOR THE POTENTIAL TREATMENT OF PLATINOSOMIASIS

KEY WORDS:

Platinossomiasis; nanoemulsions; nanotechnology; Praziquantel.

PAGES: 71
BIG AREA: Ciências da Saúde
AREA: Farmácia
SUMMARY:

Platinosomiasis is a parasitic infection primarily affecting domestic felines,

caused by trematodes of the genus Platynosomum. The parasite's life cycle is complex

and involves multiple hosts. The pathophysiology of the infection can lead to severe

hepatic damage, necessitating effective treatment strategies. Praziquantel is the first

line drug for platinosomiasis treatment; however, its bioavailability is limited due to poor

water solubility and first-pass metabolism, posing significant clinical challenges.

Therefore, the utilization of nanoemulsions, colloidal systems composed of nanometer

sized droplets, holds promise for enhancing drug absorption and efficacy. Employing

the phase inversion technique, nanoemulsions were developed, and their size, zeta

potential, pH, morphology, and stability were analyzed using dynamic light scattering

(DLS), electrophoretic mobility, and Transmission Electron Microscopy (TEM). Stable

formulations were developed; however, they exhibited significant variations over 56

days, with notable statistical differences in particle diameter. The nanoemulsions

showed size variations of 14.1 nm, 79.1 nm, and 31.4 nm. Following praziquantel

incorporation, the average particle diameter decreased 35.9 nm and 68.5 nm.

Nevertheless, while the presence of praziquantel benefited the reduction of droplet

diameter, it also introduced instability phenomena that negatively impacted formulation

efficiency. This suggests that optimizing praziquantel (PZQ) concentrations is crucial

for maximizing not only stability but also the therapeutic efficacy of these systems. The

presented nanoemulsions demonstrate good potential for the treatment of

platinosomiasis. However, further investigations are required to determine drug

dosage, encapsulation efficiency, hemolytic profile, and cytotoxicity.

COMMITTEE MEMBERS:
Externo à Instituição - FÁBIO LOPES DE MELO - Fiocruz - PE
Presidente - 2275890 - MARCELO DE SOUSA DA SILVA
Externo à Instituição - THIAGO FRANCES GUIMARÃES - Fiocruz - RJ