Banca de DEFESA: ERON LINCOLN ALVES PEREIRA

Uma banca de DEFESA de MESTRADO foi cadastrada pelo programa.
STUDENT : ERON LINCOLN ALVES PEREIRA
DATE: 20/12/2024
TIME: 09:00
LOCAL: Link de acesso para videoconferência:https://meet.google.com/aga-wbqq-vod
TITLE:

Nanoemulsions containing Coenzyme Q10 and Resveratrol as a potential strategy for the treatment of chemotherapy-induced skin hyperpigmentation.

KEY WORDS:

nanoemulsion system; nanotechnology; nanoemulsification; antioxidant activity.

PAGES: 102
BIG AREA: Ciências da Saúde
AREA: Farmácia
SUMMARY:

Cancer is a highly prevalent and incident disease worldwide, with treatments

that, while essential, often involve significant toxicity, including adverse effects such as

cutaneous hyperpigmentation. To manage this adverse effect, depigmenting agents

with antioxidant activity and/or tyrosinase-inhibiting properties, such as coenzyme Q10

(CoQ10) and resveratrol (RSV), are commonly employed. However, these molecules

present biopharmaceutical challenges, including low aqueous solubility, poor

permeability, and chemical instability. In this context, the use of nanoemulsion systems

emerges as a valuable strategy to improve formulations and overcome these

limitations. In the present study, nanoemulsions containing CoQ10 and RSV were

developed using the phase inversion composition technique and characterized in

terms of hydrodynamic diameter, polydispersity index (PDI), zeta potential, pH, infrared

spectroscopy, transmission electron microscopy, and rheology. The characterization

revealed nanoscale droplets ranging from 110 to 250 nm in size, spherical in shape,

with uniform distribution (PDI < 0.3) and anionic surface charge. Rheological analysis

demonstrated that the viscosity of the oil phase influences the system's formation.

Antioxidant profile studies showed that the nanoemulsion systems could maintain or

enhance the in vitro antioxidant capacity of the active compounds. Furthermore, the

formulations were evaluated for safety, with haemolytic potential and cell viability tests

confirming the cytocompatibility of the systems. Thus, the developed systems were

successfully characterized and tested, demonstrating satisfactory activity and safety.

COMMITTEE MEMBERS:
Presidente - 1639820 - ARNOBIO ANTONIO DA SILVA JUNIOR
Interna - 2374605 - AURIGENA ANTUNES DE ARAUJO
Externo à Instituição - FABIO ROCHA FORMIGA - FIOCRUZ