Banca de QUALIFICAÇÃO: JAMILE VITORIA ALVES FREIRE

Uma banca de QUALIFICAÇÃO de MESTRADO foi cadastrada pelo programa.
STUDENT : JAMILE VITORIA ALVES FREIRE
DATE: 12/12/2024
TIME: 09:00
LOCAL: Link de acesso para videoconferência: https://meet.google.com/orr-ycgn-rcb
TITLE:

DEVELOPMENT OF COSMETIC FORMULATIONS CONTAINING MULTI-COMPONENT SYSTEM WITH FERULIC ACID: CHARACTERIZATION AND IN VITRO SKIN RELEASE TESTS

KEY WORDS:

Ferulic Acid. Multicomponent complex. Antioxidant activity. Cosmetic formulation. In vitro skin delivery

PAGES: 78
BIG AREA: Ciências da Saúde
AREA: Farmácia
SUMMARY:

Phenolic compounds are widely used in cosmetic products for protection against ultraviolet (UV)

radiation, which can harm health and cause skin photoaging. Ferulic acid (FA) shows great

potential in mitigating these effects, standing out for its neutralizing activity against free radicals

that can cause oxidative damage to cell membranes and DNA, aiding in the prevention of

UV-induced cellular damage. However, its use is limited due to its low solubility in aqueous

media and its tendency to oxidize rapidly and decompose into inactive products, making it

unstable. To address these limitations, a multicomponent system was developed containing FA,

hydroxypropyl β-cyclodextrin (HP-β-CD), and the hydrophilic polymer PVP K30, named

Cicloferulic® (CF). Its physicochemical characterization was conducted using DSC, TG, and

FTIR tests, and HPLC analysis was performed to quantify the FA content incorporated into the

system. The antioxidant capacity of CF was also evaluated in vitro, both in isolation and when

incorporated into cosmetic formulations such as gel and emulsion at a 0.5% concentration. The

preparation method proved efficient, with a high incorporation rate of the active ingredient and

good yield. FTIR spectra confirmed the formation of the system, showing the inclusion of FA

within the cavity and its interaction with the polymer. DSC and TG curves demonstrated thermal

stability of CF similar to the cyclodextrin used, but lower than isolated FA. Although CF

exhibited superior antioxidant activity compared to isolated FA in two out of three assays, its

efficacy decreased in gel and emulsion formulations. This reduction may be due to interactions

between CF and the aqueous vehicle, which hinder the release of FA because of its affinity for

the apolar cavity of cyclodextrin (CD). This retention may limit FA's interaction with free

radicals, compromising its antioxidant capacity. Future perspectives include conducting safety

tests for Cicloferulic®, evaluating preliminary formulation stability, studying in vitro skin

release using Franz cells with optimized synthetic membranes, and determining the sun

protection factor (SPF) in vitro for CF-containing formulations.

COMMITTEE MEMBERS:
Externo à Instituição - ADRIANO ANTUNES DE SOUZA ARAÚJO - UFS
Externa ao Programa - 1679481 - ANA PAULA BARRETO GOMES - nullPresidente - 2378605 - CRISTIANE FERNANDES DE ASSIS