Banca de QUALIFICAÇÃO: KATIUSSE ALVES DOS SANTOS

Uma banca de QUALIFICAÇÃO de DOUTORADO foi cadastrada pelo programa.
STUDENT : KATIUSSE ALVES DOS SANTOS
DATE: 06/10/2025
TIME: 09:00
LOCAL: VIDEOCONFERÊNCIA
TITLE:

mirSNPs as Potential Colorectal Cancer Biomarkers: A Systematic Review

KEY WORDS:

Thyroid, cancer, biomarkers, SNPs.

PAGES: 143
BIG AREA: Ciências da Saúde
AREA: Farmácia
SUMMARY:

Thyroid cancer (TC) is the most common endocrine malignancy, with an increasing incidence

worldwide. The investigation of genetic biomarkers has shown promise in understanding disease

susceptibility and clinical behavior. This study aimed to analyze the association of single nucleotide

polymorphisms (SNPs) with the risk and prognosis of TC in a genetically admixed Brazilian

population.

Twelve SNPs were evaluated in a retrospective cohort comprising patients with TC, individuals

with benign thyroid diseases (BTD), and healthy controls. Genotyping was performed using

standardized molecular methods, and data were analyzed through logistic regression adjusted for

age and sex, considering different inheritance models.

Four polymorphisms showed statistically significant associations. SNPs rs10759944 and rs7850258

were consistently associated with an increased risk of developing TC. In contrast, rs1571443 was

associated with a protective effect against the disease. Additionally, rs949908 was linked to a lower

cancer risk among heterozygotes and with earlier tumor staging, suggesting a possible protective

role in prognosis.

These findings indicate that specific genetic variants may influence both susceptibility and clinical

progression of thyroid cancer. They also contribute to the understanding of genetic protection

mechanisms, supporting early diagnostic strategies and future applications in personalized

medicine.

COMMITTEE MEMBERS:
Externa à Instituição - LUCIANA BASTOS RODRIGUES - UFMG
Externa à Instituição - MARIA DE FATIMA PAIVA BARACHO - UFRN
Presidente - 2432313 - RAND RANDALL MARTINS