Banca de QUALIFICAÇÃO: ESTHER ARTUANNE FIGUEREDO DA SILVA

Uma banca de QUALIFICAÇÃO de MESTRADO foi cadastrada pelo programa.
STUDENT : ESTHER ARTUANNE FIGUEREDO DA SILVA
DATE: 26/08/2025
TIME: 16:00
LOCAL: Sala de aulas da GEP
TITLE:

RELATIONSHIP OF MATERNAL MORBIDITY BURDEN TO THE OCCURRENCE OF SEVERE COMPLICATIONS IN PRETERM NEONATES ADMITTED TO THE INTENSIVE CARE UNIT

KEY WORDS:

Pregnancy, Preterm Infant, Diseases

PAGES: 47
BIG AREA: Ciências da Saúde
AREA: Nutrição
SUMMARY:

Maternal clinical conditions during pregnancy are widely recognized as a determining factor for preterm birth, directly impacting fetal development. Preterm newborns (PTNBs) exposed to this adverse environment are more vulnerable to complications such as necrotizing enterocolitis (NEC), bronchopulmonary dysplasia (BPD), and extrauterine growth restriction (EUGR), which can significantly compromise their growth and development. Despite the clinical relevance and prognostic potential of these morbidities, evidence exploring the relationship between the overall burden of morbidity and the outcome of preterm infants in the neonatal intensive care unit (NICU) is still scarce. Objective: To evaluate the relationship between maternal morbidity burden and the main clinical complications in PTNBs admitted to the NICU. Methods: Prospective cohort study with 160 preterm infants admitted to a public referral maternity hospital, from October 2021 to November 2023. Maternal data (age, morbidities during pregnancy) and data from the preterm infant were collected during the NICU stay (gestational age at birth, weight at birth and at discharge from the NICU, days of parenteral nutrition use, length of hospital stay and clinical outcomes). Statistical analysis was performed considering significance when p < 0.05. Results: Most postpartum women (72.5%) had at least one morbidity, the most frequent being hypertensive syndromes of pregnancy (42.5%) and urinary tract infection (UTI) (28.7%). Among the preterm newborns, we identified that 61.3% had more severe degrees of prematurity, 48% had birth weight below 1500g and 74.8% of them had an adequate weight for corrected gestational age at discharge from the NICU. The prevalence of NEC was 6%, BPD 14%, EUGR 25.9% and death 9.4%. No statistically significant association was found between the burden of maternal morbidity and the clinical outcomes evaluated. However, the presence of maternal UTI was associated marginally with a shorter neonatal hospital stay (p = 0.050) and a lower frequency of BPD (p=0.027). Furthermore, we found a significant association between maternal age group and the presence and burden of morbidities (p < 0.001), with women aged 35 years or older presenting a higher prevalence (91.5%) and high burden (40.4% with two or more) of morbidities. Final considerations: Although we found a higher incidence of maternal morbidities among women aged 35 and older, the burden of maternal morbidities was not significantly associated with the main neonatal outcomes. The isolated presence of UTI, which was the morbidity that resulted in the shortest hospital stay and the lowest incidence of bronchopulmonary dysplasia, highlights the complexity and specificity of the relationships between maternal factors and neonatal prognosis.

COMMITTEE MEMBERS:
Interna - 838.782.974-91 - ANNA CHRISTINA DO NASCIMENTO GRANJEIRO BARRETO
Interno - 2328351 - GUSTAVO MAFALDO SOARES
Presidente - 2315640 - MARCIA MARILIA GOMES DANTAS LOPES
Externa à Instituição - RITA DE CÁSSIA SILVEIRA - UFRGS