Ementa/Descrição: |
Neste curso serão discutidos os diferentes padrões de organização estrutural e funcional de circuitos sinápticos presentes no sistema nervoso central, englobando descrições de circuitos sinápticos no córtex cerebral, amígdala, hipocampo, cerebelo, tálamo, gânglios da base e medula espinhal. Abordaremos aspectos anatômicos de conectividade, organização celular, respostas moleculares, assim como padrões eletrofisiológicos de atividade durante a codificação de comportamentos próprios de cada circuitaria. O curso é baseado na discussão de artigos científicos clássicos e contemporâneos apresentando diferentes abordagens experimentais no estudo de circuitos neurais.
|
Referências: |
Cajal, S Ramon y (1911) Histologie du systeme nerveux de lhomme et des vertebres (Translation by L. Azoulay). Paris: Maloine, 2 vols). English translation: Histology of the Nervous System of Man and Vertebrates by S. Ramon y Cajal, (Transl. by N Swanson and L Swanson) New York: Oxford University Press, 1995. Byrne JH, Castellucci VF, Kandel ER (1978) Contribution of individual mechanoreceptor sensory neurons to defensive gill-withdrawal refl ex in Aplysia. J Neurophysiol 41: 418431. The Synaptic Organization of the Brain, Gordon M. Shepherd (Oxford, 5th edition). Graybiel AM, Grillner S (2006) Microcircuits: The Interface between Neurons and Global Brain Function. Cambridge MA: MIT Press. Handbook of Brain Microcircuits, G.Shepherd & S. Grillner (2010) Oxford University Press. Chen WR, Shepherd GM. The olfactory glomerulus: a cortical module with specific functions. J Neurocytol. 2005 Sep;34(3-5):353-60. Douglas RJ, Martin KA. Neuronal circuits of the neocortex. Annu Rev Neurosci. 2004;27:419-51.Turner DA, Buhl EH, Hailer NP, Nitsch R. Morphological features of the entorhinal-hippocampal connection. Prog Neurobiol. 1998 Aug;55(6):537-62. Silberberg G, Grillner S, LeBeau FE, Maex R, Markram H. (2005) Synaptic pathways in neural microcircuits. Trends Neurosci 28:541551. Herry C , Ciocchi S , Senn V , Demmou L , Muller C , Luthi A (2008) Switching on and off fear by distinct neuronal circuits . Nature 454 : 600606. Maren S , Quirk GJ (2004) Neuronal signalling of fear memory . Nat Rev Neurosci 5 : 844 852. Johnson LR , Ledoux JE , Doyere V (2009) Hebbian reverberations in emotional memory micro circuits . Front Neurosci. Amaral D , Lavenex P (2007) Hippocampal neuronatomy . In: Andersen P , Morris R , Amaral D , Bliss T , OKeefe J , eds. The Hippocampus Book , pp. 37114 . New York : Oxford University Press. Klausberger T , Somogyi P (2008) Neuronal diversity and temporal dynamics: the unity of hippocampal circuit operations . Science 321 : 5357. Freund TF , Buzs.ki G (1996) Interneurons of the hippocampus . Hippocampus 6 : 347470. Harris KD , Csicsvari J , Hirase H , Dragoi G , Buzs.ki G. (2003) Organization of cell assemblies in the hippocampus . Nature 424 : 552 556 . Hafting T , Fyhn M , Molden S , Moser M-B , Moser EI (2005) Microstructure of a spatial map in the entorhinal cortex . Nature 436 : 801 806. |